Fig. 2

Cell extrinsic and intrinsic cues during asymmetric division. A Extracellular microenvironment (local niche) provides cell extrinsic cues to induce asymmetric stem cell division. B Cell intrinsic non-canonical pathway is involved in regulating asymmetric stem cell division. Some growth-signaling pathways are involved in regulating asymmetric division of stem cells, such as MYC. On the other side, Brat (Drosophila) or TRIM32 (mammalian) ubiquitinates c-MYC leading to cell differentiation (i). Some self-renewal or differentiation transcription factors are accumulated on the side of stem cell or differentiated cell to regulate asymmetric division (ii). microRNAs regulate asymmetric division of stem cells. miR-146a and Lnc34a accumulating in the stem cell side drives stem renewal, whereas miR-34a, Let-7 and LincGET accumulating in the other side drives cell differentiation (iii)