Fig. 2From: Wnt/β-catenin signaling in heart regenerationRoles of Wnt/β-catenin signaling during vertebrate heart development. Wnt/β-catenin signaling is required for heart development in a biphasic manner: while the activation of the pathway promotes mesoderm specification in early phases of hESC differentiation, it hampers CM differentiation at later stages. This late-stage suppression can act through the cardiac differentiation inducer Mesp1, which activates the Wnt inhibitor Dkk1. Wnt/β-catenin signaling can also regulate CM proliferation through Gsk3 by regulating β-catenin activityBack to article page