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Cell Regeneration
Fig. 3 | Cell Regeneration

Fig. 3

From: Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

Fig. 3

The infiltration of CD4+ helper and CD8+ cytotoxic T lymphocytes into human grafts. A, B Immunofluorescent analysis of CD4+ helper T (arrow) lymphocytes in human grafts of Mk #1 at 4 months, Mk #2 at 8 months, and Mk #3 at 12 months p.t. with continuous CsA treatment, and Mk #4 at 10 months p.t. with discontinuous CsA treatment. Cell nuclei were counterstained with DAPI. C Percentages of CD4+ T lymphocytes in human grafts of Mk #1, Mk #2, Mk #3, and Mk#4 shown in (A and B). D, E Immunofluorescent analysis of CD8+ cytotoxic T (arrow head) lymphocytes in human grafts of Mk #1 at 4 months, Mk #2 at 8 months, and Mk #3 at 12 months p.t. with continuous CsA treatment, and Mk #4 at 10 months p.t. with discontinuous CsA treatment. Cell nuclei were counterstained with DAPI. F Percentages of CD8+ T lymphocytes in human grafts of Mk #1, Mk #2, Mk #3, and Mk #4 shown in (D and E). Scale bars: 50 μm in (A, B and D-E). Data are represented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ns (not significant)

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