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Cell Regeneration

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  1. Content type: Research article

    We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity n...

    Authors: Wuhong Pei, Sunny C. Huang, Lisha Xu, Kade Pettie, María Laura Ceci, Mario Sánchez, Miguel L. Allende and Shawn M. Burgess

    Citation: Cell Regeneration 2016 5:3

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  2. Content type: Review

    Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19–24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Em...

    Authors: Young Jin Lee, Suresh Ramakrishna, Himanshu Chauhan, Won Sun Park, Seok-Ho Hong and Kye-Seong Kim

    Citation: Cell Regeneration 2016 5:2

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  3. Content type: Research article

    Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptio...

    Authors: Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang…

    Citation: Cell Regeneration 2015 4:12

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  4. Content type: Review

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has o...

    Authors: Zhijuan Mao, Suming Zhang and Hong Chen

    Citation: Cell Regeneration 2015 4:11

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  5. Content type: Review

    Tissue-engineered constructs are promising to overcome shortage of organ donors and to reconstruct at least parts of injured or diseased tissues or organs. However, oxygen and nutrient supply are limiting fact...

    Authors: Karoline Pill, Sandra Hofmann, Heinz Redl and Wolfgang Holnthoner

    Citation: Cell Regeneration 2015 4:8

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  6. Content type: Review

    Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, dev...

    Authors: Hoi-Hung Cheung, Duanqing Pei and Wai-Yee Chan

    Citation: Cell Regeneration 2015 4:6

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  7. Content type: Methodology

    In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a heterogeneous cell pop...

    Authors: Eleni Oberbauer, Carolin Steffenhagen, Christoph Wurzer, Christian Gabriel, Heinz Redl and Susanne Wolbank

    Citation: Cell Regeneration 2015 4:7

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  8. Content type: Research

    Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of...

    Authors: Ke Huang, Juan Du, Ning Ma, Jiajun Liu, Pengfei Wu, Xiaoya Dong, Minghui Meng, Wenqian Wang, Xin Chen, Xi Shi, Qianyu Chen, Zhongzhou Yang, Shubin Chen, Jian Zhang, Yuhang Li, Wei Li…

    Citation: Cell Regeneration 2015 4:4

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  9. Content type: Research

    The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost fish and amphibians can regenerate...

    Authors: Gunes Ozhan and Gilbert Weidinger

    Citation: Cell Regeneration 2015 4:3

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  10. Content type: Short report

    Endothelial cells line the luminal surface of blood vessels and form a barrier between the blood and other tissues of the body. Ets variant 2 (ETV2) is transiently expressed in both zebrafish and mice and is nece...

    Authors: Anne G Lindgren, Matthew B Veldman and Shuo Lin

    Citation: Cell Regeneration 2015 4:1

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  11. Content type: Short report

    Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linage differentiation capabilities. While much work has been done to optimize the differentiation media, few stud...

    Authors: Mark Ahearne, Joanne Lysaght and Amy P Lynch

    Citation: Cell Regeneration 2014 3:13

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  12. Content type: Research

    The prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) is a simple, robust and efficient technique for gene targeting in model organisms such as zebrafish, mi...

    Authors: Quanmei Yan, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengcheng Tang, Nana Fan and Liangxue Lai

    Citation: Cell Regeneration 2014 3:12

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  13. Content type: Research

    The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interesting candidate gene to improve disease resistance in farm animals. In this study, we report the use o...

    Authors: Quanmei Yan, Huaqiang Yang, Dongshan Yang, Bentian Zhao, Zhen Ouyang, Zhaoming Liu, Nana Fan, Hongsheng Ouyang, Weiwang Gu and Liangxue Lai

    Citation: Cell Regeneration 2014 3:11

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  14. Content type: Short report

    SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationa...

    Authors: Kamesh Narasimhan, Kevin Micoine, Emmanuel Lacôte, Serge Thorimbert, Edwin Cheung, Bernold Hasenknopf and Ralf Jauch

    Citation: Cell Regeneration 2014 3:10

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  15. Content type: Short report

    The transcription factor Oct4 (Pou5f1) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore, Oct4 expression might identify somatic stem cell populations with inheren...

    Authors: Anne Limbourg, Sabine Schnabel, Vladimir J Lozanovski, L Christian Napp, Teng-Cheong Ha, Tobias Maetzig, Johann Bauersachs, Hassan Y Naim, Axel Schambach and Florian P Limbourg

    Citation: Cell Regeneration 2014 3:9

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  16. Content type: Review

    Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their di...

    Authors: Guangming Wu and Hans R Schöler

    Citation: Cell Regeneration 2014 3:7

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  17. Content type: Commentary

    Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and ...

    Authors: Xuecong Wang and Ralf Jauch

    Citation: Cell Regeneration 2014 3:6

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  18. Content type: Research

    The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluri...

    Authors: Aline C Planello, Junfeng Ji, Vivek Sharma, Rajat Singhania, Faridah Mbabaali, Fabian Müller, Javier A Alfaro, Christoph Bock, Daniel D De Carvalho and Nizar N Batada

    Citation: Cell Regeneration 2014 3:4

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