Table 1 Reprogramming modulators

Transcription factor

Esrrb(Orphan nuclear receptor )

replace Klf4

[55]

Nr5a2(Orphan nuclear receptor )

replace Oct4

[56]

Sall4

increase the efficiency of reprogramming

[57]

C/EBPα

reprogramming of mature B cells

[58]

UTF-1(ESC-specific transcription factor )

increase the efficiency of reprogramming

[59]

SV40 LT

increase the efficiency of reprogramming

[60]

miR-291-39, miR-294, miR-295

increase the efficiency of reprogramming

[62, 63]

miR-372, miR-302/367

[75, 76]

hTERT

increase the efficiency of reprogramming

[61]

TGFβ

antagonist increase the efficiency of reprogramming

[65–67]

Wnt3a

increase the efficiency of reprogramming

[68]

BMP4

replace Klf4

[64]

Epigenetic regulators

HDACs

inhibition increase the efficiency of reprogramming

[69–71]

G9a

increase the efficiency of reprogramming

[72]

DNMT1

inhibition promote fully reprograming

[73, 74]