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Table 1 Reprogramming modulators

From: Progress and bottleneck in induced pluripotency

Category Function Reference
Transcription factor
Esrrb(Orphan nuclear receptor ) replace Klf4 [55]
Nr5a2(Orphan nuclear receptor ) replace Oct4 [56]
Sall4 increase the efficiency of reprogramming [57]
C/EBPα reprogramming of mature B cells [58]
UTF-1(ESC-specific transcription factor ) increase the efficiency of reprogramming [59]
SV40 LT increase the efficiency of reprogramming [60]
miR-291-39, miR-294, miR-295 increase the efficiency of reprogramming [62, 63]
miR-372, miR-302/367   [75, 76]
hTERT increase the efficiency of reprogramming [61]
TGFβ antagonist increase the efficiency of reprogramming [6567]
Wnt3a increase the efficiency of reprogramming [68]
BMP4 replace Klf4 [64]
Epigenetic regulators
HDACs inhibition increase the efficiency of reprogramming [6971]
G9a increase the efficiency of reprogramming [72]
DNMT1 inhibition promote fully reprograming [73, 74]