Progress and bottleneck in induced pluripotency

Cell Regeneration

Table 2 Small molecules that promote reprogramming

Compound	Function	Reference
Valproic acid	histone deacetylase inhibitor	[70]
Trichostatin A	histone deacetylase inhibitor	[70]
Sodium butyrate	histone deacetylase inhibitor	[70]
BIX-01294	histone methyl transferase inhibitor	[89]
Parnate	histone demethylase inhibitor	[90]
5-azacytidine	DNA methyltransferase inhibitor	[74]
RG108	DNA methyltransferase inhibitor	[89]
SB431542 + PD0325901	ALK5 inhibitor + MEK inhibitor	[67]
A-83-01	TGFβ receptor inhibitor	[92]
CHIR99021	GSK3 inhibitor	[67]
RepSox	Tgfbr1 kinase inhibitor	[65]
PS48	activator of PDK1	[92]
Vitamin C	nutrient vital that lower reactive oxygen species	[93]