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Table 2 Gene ontology of genes associated with differentially methylated regions

From: Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

iPS type

GO Biological process

P-value

FDR Q-value

Fold enrichment

Y-iPSCs

Regulation of glial cell proliferation

5.72 × 10-13

5.01 × 10-9

8.2103

Y-iPSCs

Intestinal epithelial cell differentiation

2.98 × 10-11

4.35 × 10-8

10.7333

Y-iPSCs

Stem cell development

6.19 × 10-6

9.04 × 10-4

2.247

Y-iPSCs

Stem cell maintenance

6.81 × 10-6

9.63 × 10-4

2.2958

T-iPSCs

Eye development

3.81 × 10-11

6.68 × 10-8

6.5284

T-iPSCs

Spinal cord development

3.68 × 10-9

3.58 × 10-6

2.4715

T-iPSCs

Limb bud formation

6.50 × 10-6

1.09 × 10-3

3.1573

  1. GREAT tool [22] was used annotate genes with aberrant methylation in their transcription start site.