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Figure 1 | Cell Regeneration

Figure 1

From: Pharmacological manipulation of transcription factor protein-protein interactions: opportunities and obstacles

Figure 1

Advantages of targeting transcription factor protein-protein interactions over conventional targets. Targeting upstream cell-signaling nodes (e.g., kinase) lacks specificity because of the interconnected nature of cell signaling and its numerous feedback loops. Targeting transcription factors, downstream effectors of cell signaling, able to control specific gene groups via specific protein associations, is likely to be a more specific approach [13].

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