Fig. 3From: Wnt/β-catenin signaling in heart regenerationWnt-dependent and Wnt-independent roles of secreted Frizzled-related proteins (sFrps). sFrp-2 can block hypoxia-induced CM apoptosis by activating a Wnt/β-catenin pathway. On the other hand, sFrp-2 can induce collagen deposition and fibrosis via enhancing Bmp1 function, which occurs through a Wnt-independent pathwayBack to article page