Fig. 1
From: Regulatory functions and pathological relevance of the MECP2 3′UTR in the central nervous system
Regulation via the MECP2 3'UTR. a Schematic depicting the cis-acting regulatory elements in the genomic sequence of the MECP2 3'UTR. Open boxes indicate the silencer and enhancer described by Liu and Francke [59]. Closed, colored boxes indicate auxiliary elements involved in polyadenylation, as described by Newnham et al. [58]. E exon, GRS G-rich element, USE upstream sequence element. b Four unique MECP2 transcripts produced by alternative polyadenylation. c Relative position of putative miRNA binding sites in the 3'UTR of the 10.2-kb species of MECP2 mRNA, as defined by Target Scan. This representation is limited to predicted sites for miRNAs that are broadly conserved in vertebrates (with the exception of the human-specific site for miR-483-5p)