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Figure 3 | Cell Regeneration

Figure 3

From: Progress and bottleneck in induced pluripotency

Figure 3

Tumor suppressor p53 inhibits induced pluripotency. p53 is activated by oncogenic stresses and DNA damage during reprogramming, leading to cell cycle arrest, apoptosis, or senescence, which all limit successful reprogramming. Upon activation, p53 also suppresses the expression of Nanog that is required for the transition from pre-iPSCs to iPSCs.

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