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Fig. 2 | Cell Regeneration

Fig. 2

From: Wnt/β-catenin signaling in heart regeneration

Fig. 2

Roles of Wnt/β-catenin signaling during vertebrate heart development. Wnt/β-catenin signaling is required for heart development in a biphasic manner: while the activation of the pathway promotes mesoderm specification in early phases of hESC differentiation, it hampers CM differentiation at later stages. This late-stage suppression can act through the cardiac differentiation inducer Mesp1, which activates the Wnt inhibitor Dkk1. Wnt/β-catenin signaling can also regulate CM proliferation through Gsk3 by regulating β-catenin activity

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