Skip to main content

Advertisement

Fig. 1 | Cell Regeneration

Fig. 1

From: The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis

Fig. 1

Expression of glucose and glycogen metabolism genes in the skeletal muscle of wild-type and SOD1G93A mice. Compared to non-transgenic wild-type mice (white bars), the expression of glucose and glycogen metabolism genes in the skeletal muscle of SOD1G93A mice (black bars) does not increase over the assessed period of muscle growth. Disease stages by age: pre-symptomatic (5 weeks), onset (8 weeks), mid-stage (18 weeks), and end-stage (24 weeks). Green upward arrows illustrate a significant effect (p < 0.05) of age following analysis by two-way ANOVA. Blue arrows represent no effect of age (p > 0.05) following analysis by two-way ANOVA. For SOD1G93A mice, relative expression of Phkg1 mRNA declined with age (illustrated by red downward arrow). The effect of age on gene expression was further interrogated using multiple comparison assessment with Bonferroni post hoc analysis; *significant differences (p < 0.05) at 8, 18, and 24 weeks of age when compared to 5 weeks of age. An effect of genotype within each age (5, 8, 18, and 24) was interrogated using multiple comparison assessment with Bonferroni post hoc analysis; #significant (p < 0.05) differences between WT and SOD1G93A mice at 5, 8, 18, or 24 weeks of age (n = 6 mice/group). Data presented as mean ± SEM. Gene descriptions, symbols, UniGene identifiers, and NCBI reference sequences (NCBI RefSeq) are provided in Table 1

Back to article page