Skip to main content


Table 1 miRNAs that are known to target the MECP2 3'UTR and the reported biological significance for each

From: Regulatory functions and pathological relevance of the MECP2 3′UTR in the central nervous system

microRNA Biological relevance Reference
miR-132 Homeostatic regulation of MeCP2 and BDNF. Klein et al. (2007) [76]
Reduction of miR-132 during ischemic-preconditioning contributes to elevated MeCP2 levels in the cortex following ischemic injury. Lusardi et al. (2010) [94]
miR-212 Differential regulation of MeCP2 and BDNF in response to prolonged cocaine intake. Im et al. (2010) [79]
miR-7b Homeostatic regulation of MeCP2 during postnatal development. Chen et al. (2014)
miR-483-5p Human-specific regulation of MeCP2 expression during fetal development. Han et al. (2013) [81]
miR-124a May attenuate nociception by repressing MeCP2 and, by extension, downstream pro-inflammatory genes. Kynast et al. (2013) [82]
miR-22 MeCP2-targeting during ischemic-preconditioning reduces apoptosis and cardiac fibrosis. Feng et al. (2014) [84]
Smooth muscle cell differentiation. Zhao et al. (2015) [83]
miR-511 Only binds MECP2 3'UTR carrying C > T SNP. Reduces peripheral MeCP2 expression by ~50 % and has implications for aggression. Tantra et al. (2014) [93]