Fig. 1
From: Deer antler renewal gives insights into mammalian epimorphic regeneration
Histogenesis of a regenerating antler bud. A Sagittally-cut histological section of a pedicle stump immediately after hard antler casting; note the rough casting surface. B Epidermis of the skin rim formed by distal pedicle skin; note that this epidermis became thickened and acquired some velvet skin features. C The thickened hyperplastic perichondrium formed directly by distal pedicle periosteum (PP). D Sagittally-cut section of an early regenerating antler bud over a pedicle stump; note that circumferential cartilaginous callus (CCC) had formed at the anterior and posterior sites (two arrows). EÂ Sagittally-cut section of a regenerating antler bud; note that rapidly-accumulating tissue mass in each CCC had pushed anterior and posterior corners laterally and distally (two arrows), and that the posterior and anterior bulges were the growth centres for the formation of the main beam and brow tine of the antler. Arrow: developing hair follicles; Arrowhead: sebaceous glands. PP: pedicle periosteum