Fig. 3

COX deletion inhibits the MSC-CM-induced organoid swelling. A, B Representative images of COX1 (A) or COX2 (B) distributions in Gli1-tomato cells in mouse small and large intestine. C Proportions of Gli1⁺ cells in COX1⁺ or COX2⁺ cells in mouse small (SI) and large intestine (LI). D Time-lapse imaging and surface area quantification of small intestinal organoids with stimulation using mMSC-CM from Ctrl or Gli1-Ptgs^cKO mice. Scale bar, 100 μm. Data represent mean ± SD of three independent experiments. ***P < 0.001, one-way ANOVA (D)