Fig. 5
From: The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling
COX deletion aggravates DSS-induced epithelial injuries in colon. A Schematic diagram showing the timepoint for tamoxifen injection and DSS treatment. B The survival rate of Gli1-PtgscKO and Ctrl mice (n = 6 per genotype). C Representative structures of Gli1-PtgscKO and Ctrl mouse colon after DSS treatment indicated by H&E staining. Mice treated with 3% DSS for 5 days followed by 2-day water feeding were sacrificed. Scale bar, 100 μm. D Histological score of Gli1-PtgscKO and Ctrl mice after DSS treatment (n = 5 per genotype). E Body weight and disease activity index of Gli1-PtgscKO and Ctrl mice after DSS treatment (n = 5 per genotype). F Immunofluorescent staining of CD45 in Gli1-PtgscKO and Ctrl mouse colon after DSS treatment. Scale bar, 100 μm. Data represent mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, Log-rank test (B), unpaired two-tailed t-test (D), Friedman test (E)