Fig. 4

Gene regulatory networks (GRNs) underlie differential properties in human HSPCs. A UMAP plot based on the regulon activity score colored by samples (left) or pseudotime developmental path (right). B Pairwise correlation plot of regulons in different HSPCs. Regulon activity score and co-relation score are indicated by different colors. 6 highly co-related regulon modules are highlighted. C GO enrichment analyses on 6 co-related regulon modules. The most enriched GO terms in each module are shown. The p-values for each GO term smaller than \(1\times {10}^{-3}\) are shown and highlighted for those smaller than \(1\times {10}^{-7}\). D Distribution of six regulon modules in different cell types. E–G Regulatory networks by indicated regulon modules. The blue dots indicate genes which are shared targets of two regulators and the purple dots indicate genes which are shared targets of more than two regulators. GO analysis is performed on target genes shared at least by two regulators in each module