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  1. Research article

    Loss of Mgat5a-mediated N-glycosylation stimulates regeneration in zebrafish

    We are using genetics to identify genes specifically involved in hearing regeneration. In a large-scale genetic screening, we identified mgat5a, a gene in the N-glycosylation biosynthesis pathway whose activity n...

    Wuhong Pei, Sunny C. Huang, Lisha Xu, Kade Pettie, María Laura Ceci, Mario Sánchez, Miguel L. Allende and Shawn M. Burgess

    Cell Regeneration 2016 5:3

    Published on: 20 October 2016

  2. Research article

    Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo

    Currently, direct conversion from somatic cells to neurons requires virus-mediated delivery of at least one transcriptional factor or a combination of several small-molecule compounds. Delivery of transcriptio...

    Songwei He, Yiping Guo, Yixin Zhang, Yuan Li, Chengqian Feng, Xiang Li, Lilong Lin, Lin Guo, Haitao Wang, Chunhua Liu, Yi Zheng, Chuanming Luo, Qiang Liu, Fuhui Wang, Hao Sun, Lining Liang…

    Cell Regeneration 2015 4:12

    Published on: 30 December 2015

  3. Review

    Stem cell therapy for amyotrophic lateral sclerosis

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has o...

    Zhijuan Mao, Suming Zhang and Hong Chen

    Cell Regeneration 2015 4:11

    Published on: 19 November 2015

  4. Review

    Stem cell aging in adult progeria

    Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, dev...

    Hoi-Hung Cheung, Duanqing Pei and Wai-Yee Chan

    Cell Regeneration 2015 4:6

    Published on: 3 October 2015

  5. Methodology

    Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art

    In the past decade, adipose tissue became a highly interesting source of adult stem cells for plastic surgery and regenerative medicine. The isolated stromal vascular fraction (SVF) is a heterogeneous cell pop...

    Eleni Oberbauer, Carolin Steffenhagen, Christoph Wurzer, Christian Gabriel, Heinz Redl and Susanne Wolbank

    Cell Regeneration 2015 4:7

    Published on: 30 September 2015

  6. Research

    GATA2−/− human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment

    Hematopoiesis is a progressive process collectively controlled by an elaborate network of transcription factors (TFs). Among these TFs, GATA2 has been implicated to be critical for regulating multiple steps of...

    Ke Huang, Juan Du, Ning Ma, Jiajun Liu, Pengfei Wu, Xiaoya Dong, Minghui Meng, Wenqian Wang, Xin Chen, Xi Shi, Qianyu Chen, Zhongzhou Yang, Shubin Chen, Jian Zhang, Yuhang Li, Wei Li…

    Cell Regeneration 2015 4:4

    Published on: 5 August 2015

  7. Research

    Wnt/β-catenin signaling in heart regeneration

    The ability to repair damaged or lost tissues varies significantly among vertebrates. The regenerative ability of the heart is clinically very relevant, because adult teleost fish and amphibians can regenerate...

    Gunes Ozhan and Gilbert Weidinger

    Cell Regeneration 2015 4:3

    Published on: 8 July 2015

  8. Research

    Generation of multi-gene knockout rabbits using the Cas9/gRNA system

    The prokaryotic clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) is a simple, robust and efficient technique for gene targeting in model organisms such as zebrafish, mi...

    Quanmei Yan, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengcheng Tang, Nana Fan and Liangxue Lai

    Cell Regeneration 2014 3:12

    Published on: 27 September 2014

  9. Research

    Production of transgenic pigs over-expressing the antiviral gene Mx1

    The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interesting candidate gene to improve disease resistance in farm animals. In this study, we report the use o...

    Quanmei Yan, Huaqiang Yang, Dongshan Yang, Bentian Zhao, Zhen Ouyang, Zhaoming Liu, Nana Fan, Hongsheng Ouyang, Weiwang Gu and Liangxue Lai

    Cell Regeneration 2014 3:11

    Published on: 26 September 2014

  10. Short report

    Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors

    SOX transcription factors constitute an attractive target class for intervention with small molecules as they play a prominent role in the field of regenerative biomedicine and cancer biology. However, rationa...

    Kamesh Narasimhan, Kevin Micoine, Emmanuel Lacôte, Serge Thorimbert, Edwin Cheung, Bernold Hasenknopf and Ralf Jauch

    Cell Regeneration 2014 3:10

    Published on: 19 July 2014

  11. Short report

    Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin

    The transcription factor Oct4 (Pou5f1) is a critical regulator of pluripotency in embryonic and induced pluripotent stem cells. Therefore, Oct4 expression might identify somatic stem cell populations with inheren...

    Anne Limbourg, Sabine Schnabel, Vladimir J Lozanovski, L Christian Napp, Teng-Cheong Ha, Tobias Maetzig, Johann Bauersachs, Hassan Y Naim, Axel Schambach and Florian P Limbourg

    Cell Regeneration 2014 3:9

    Published on: 14 June 2014

  12. Commentary

    Bioengineering of a human whole tooth: progress and challenge

    A major challenge in stem cell-based bioengineering of an implantable human tooth is to identify appropriate sources of postnatal stem cells that are odontogenic competent as the epithelial component due to th...

    Yanding Zhang and YiPing Chen

    Cell Regeneration 2014 3:8

    Published on: 30 April 2014

  13. Review

    Role of Oct4 in the early embryo development

    Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their di...

    Guangming Wu and Hans R Schöler

    Cell Regeneration 2014 3:7

    Published on: 29 April 2014

  14. Commentary

    OCT4: A penetrant pluripotency inducer

    Native OCT4 protein has the intrinsic ability of crossing cellular membranes to enter cells. This finding could revive efforts to induce pluripotency with proteins replacing nucleic acid-based approaches, and ...

    Xuecong Wang and Ralf Jauch

    Cell Regeneration 2014 3:6

    Published on: 31 March 2014

  15. Commentary

    A mitochondrial strategy for safeguarding the reprogrammed genome

    Genomic aberrations induced by somatic cell reprogramming are a major drawback for future applications of this technology in regenerative medicine. A new study by Ji et al. published in Stem Cell Reports sugge...

    Alessandro Prigione and James Adjaye

    Cell Regeneration 2014 3:5

    Published on: 29 March 2014

  16. Research

    Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

    The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involves epigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluri...

    Aline C Planello, Junfeng Ji, Vivek Sharma, Rajat Singhania, Faridah Mbabaali, Fabian Müller, Javier A Alfaro, Christoph Bock, Daniel D De Carvalho and Nizar N Batada

    Cell Regeneration 2014 3:4

    Published on: 7 February 2014

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